How to position the position of the surgical robot industry

In recent years, the demand for huge high-end technology for the diagnosis and treatment of various diseases, the social pressure of aging on the support and care of the elderly, and the contradiction between supply and demand caused by the lack of high-quality medical personnel have driven these three factors. The medical intelligence is becoming more and more prominent. Various machines are poured into the operating room, and robots are also promoted in the medical system.

On September 6th, the Da Vinci surgical robot of Tangdu Hospital of the Fourth Military Medical University of Xi'an completed the first thoracic surgery after the settlement. Successfully removed a tumor with a diameter of about 10 cm for a patient. This is the world's first auxiliary robot under the xiphoid process. Invasive upper thymoma resection.

Medical robots refer to robots used in hospitals, clinics, medical or auxiliary medical care, and health services. Depending on the function, medical robots can be divided into surgical robots, exoskeleton rehabilitation robots and nursing robots. Among them, surgical robots have attracted much attention. From the development of surgical robots, the following three surgical robots are the most typical.

A, surgical robot Aesop

In 1994, the surgical robot Aesop developed by ComputerMoTIon of the United States was a mirror-held robot. Mainly used to adjust the position of the laparoscope, usually controlled by voice or foot.

Surgical robot Aesop

This robot has three phases: Aesop-1000, Aesop-2000 and Aesop-3000. It can mimic the movement of human arm, without the need for medical personnel to control the endoscope by hand, more precise operation, making the doctor's vision more stable and direct.

B, surgical robot Zeus

In 1996, Computer MoTIon of the United States developed Zeus on the basis of Aesop robots. It can be operated remotely and is divided into Surgeon-side system and PaTIent-side system.

Surgical robot Zeus

The surgical robot Zeus consists of three robot arms, a console and a computer controller. The doctor can voice-operate the laparoscope arm while operating the other two robotic arms for surgery.

C, surgical robot Da Vinci

Da Vinci is arguably the most popular surgical robot. It was developed by IntuiTIveSurgical in 1999 and is based on the basic model of Zeus.

Surgery robot Da Vinci

At present, there are more than 50 Da Vinci robotic surgical systems installed in mainland China. Although it is not much more than 2,000 in the United States and 230 in Japan, the usage rate is the highest in the world.

Da Vinci has now launched four generations of products:

In 1996, the first generation of Da Vinci robots was launched.

The second generation of the product was introduced in 2006, with a wider range of robotic arms, allowing doctors to perform multi-picture observations without leaving the console.

In 2009, on the second generation, the dual-console, analog controller, intraoperative fluorescence development technology and other functions were added, and the third generation product was introduced.

The fourth generation of robots was launched in 2014, and the flexibility, precision, and image clarity have been improved. The company also developed a remote observation and guidance system in the second half of 2014.

In August 2015, on the occasion of the 11th anniversary of Google's listing, Wall Street made an interesting statistic. It counted the US stock companies whose stock returns exceeded Google's (1277%) in 11 years since Google's listing. Of the 6,000 US stock companies, only 13 have a higher rate of return than Google, and one of them, called Intuitive Surgical, has far more returns than Google.

The Da Vinci Surgical Robot is an advanced robotic platform designed to perform complex surgical procedures using minimally invasive methods. Da Vinci surgical robot is the most advanced minimally invasive surgical treatment platform. It makes the precision of surgery surpass the limit of human hand. It is a revolutionary leap for the whole surgical concept, especially urology. In the elite field of surgery, the disease adapts to a wide range.

What is the Da Vinci surgical robot?

The Da Vinci Surgical Robot is an advanced robotic platform consisting of a surgeon's console, a bedside robotic arm system, and an imaging system.

1. Surgeon console: The surgeon is sitting in the console, outside the sterile area of ​​the operating room, using both hands (by operating the two main controllers) and the feet (via the foot pedals) to control the instrument and a 3D HD Looking into the mirror. As seen in the stereoscopic eyepiece, the surgical instrument tip moves in synchrony with the surgeon's hands.

2. Bedside robotic arm system: The bedside robotic arm system (Patient Cart) is the operating component of the surgical robot. Its main function is to provide support for the instrument arm and the camera arm. The assistant doctor works in the bedside robotic system in the sterile area and is responsible for changing the instruments and endoscopes to assist the surgeon in completing the operation. To ensure patient safety, the assistant doctor has higher priority over the movement of the bedside robotic system than the surgeon.

3. Imaging system: The image processor (Video Cart) contains the core processor of the surgical robot and the image processing equipment. It is located outside the sterile area during the operation, and can be operated by the patrolling nurse and can be equipped with various auxiliary surgical equipment. The endoscope of the surgical robot is a high-resolution three-dimensional (3D) lens, which has a magnification of 10 times or more for the surgical field of view, and can bring a three-dimensional high-definition image of the patient's body cavity to the surgeon, so that the surgeon has more common laparoscopic surgery. It can better grasp the operating distance, more identifiable anatomical structure and improve the accuracy of surgery.

How was the Da Vinci surgical robot born?

The Da Vinci robot technology originated from the Stanford Research Institute (SRI) with an official background. At the end of the 1980s, a group of scientists began research and development of surgical robots at the Stanford Research Institute. The original intention was to develop a suitable surgery for the field. robot.

The Da Vinci surgical robot has been updated to the fourth generation since 1996, and the flexibility and precision have been greatly improved, but the development of surgical robots has not stopped at "Da Vinci". Dr. Frederic H. Moll, the founder of Intuitive Surgical, the founder of Intuitive Surgical, the first to introduce surgical robots to medical practice, is now creating another surgical robot for more fields: the ARES robot.

Moll has more than 20 years of experience in medical equipment and high-tech medical fields. What he knows widely in the industry is his great contribution to medical technology companies. In the early 1980s, he was involved in an internship with a surgical resident at the Manson Medical Center in Virginia, Seattle, and found that the invasiveness of surgical bacteria caused even more damage to the patient than the disease being treated. "The large incision caused by open surgery on the human body is really shocking," Moll recalls. "This is too backward." So he applied for a vacation to Silicon Valley, and the original position has been retained for 10 years, but He never went back.

In 1994, a non-profit research firm called SRI International invested in a remote surgery system for the battlefield that was much smaller than the wounds and injuries created by manual surgery. This coincided with Moll's wish, so it was suggested that the Guidant company at that time developed similar medical equipment, but was denied because the risk of robotic surgery was too large to be put into commercial use.

In 1995, Moll resigned from Guidant, co-founded Intuitive Surgical Medical Robots with John Freund and Rob Younge, bringing the Da Vinci surgical robots that enable minimally invasive machine surgery to the public at an average price of $1.3 million. In 2000, the company was listed at $9 per share; in 2003, it acquired rival Computer Motion. Since then, Intuitive's sales have risen sharply, completely dispelling Wall Street's doubts about the commercial value of Intuitive surgical robots.

"Da Vinci" three major components

"Da Vinci" three major components: surgeon console, bedside robot system, imaging system

Established Hansen Medical in 2002: Focus on more detailed areas of medical robot Sensei

Dr Frederic H. Moll

Dr Frederic H. Moll

Before the founding of the industry-famous Intuitive Surgical, Dr. Moll had two attempts to start a company:

Founded Endotherapeutics Medical Equipment Company in 1984 and Origin Medsystems Surgery Equipment Company in 1989.

In addition, he also served as medical director in the surgical equipment division of Guidant. Moll is often in a multi-disciplinary position and has served as a director or consultant for a long list of medical companies during the decades of developing his own products: MAKO, Shockwave, Cephea, Innovative Spinal Technologies, BIOLASE, RefleXion Medical Intersect ENT, Restoration Robotics, AcousTx, Aptus Endosystems, Leptos Biomedical, Catalyst Health Ventures Ventures, Kearny Venture Partners Ventures.

Moll's depth of exploration in the field of medical devices is staggering. In 2002, Frederic Moll left his own Intuitive and founded Hansen Medical. He hopes to create a more technical robot that precisely positions, operates, and stably controls a very thin and flexible catheter that is implanted into the heart for minimally invasive surgery.

Hansen Medical manufactures robotic surgical systems and a range of tools for catheters, catheters, sheaths, balloons, stents, etc., including SenseiTM robotic catheter systems for cardiovascular surgery and Magellan for peripheral vascular surgery. TM robot system, Artisan® control catheter, CoHesionTM 3D visualization module.

Unlike "Da Vinci", the key product Sensei robotic surgery system focuses on more detailed areas, such as incision of small orifices from the large blood vessels of the arms or thighs, introduction of surgical tools with catheters, and surgery for blood circulation. . Due to a conflict with the original Intuitive Surgical business, Hansen signed an intellectual property agreement to pay 3% of sales revenue to Intuitive and will cooperate with some cardiac surgery businesses.

The most amazing thing is that in 2007, Moll founded Auris Surgery Robotics. Nearly a decade has passed, and today we are opening the homepage of Auris Surgical Robotics. There is still only one sentence, "Auris Surgical Robotics is a technology company from Silicon Valley." Regarding the company's business and development, the official is almost nothing to mention. However, from the outside world, Auris did not have products during these years, but it attracted many excellent venture capitalists: in March 2014, A round of financing 34.38 million; in September 2015, financing 150 million yuan. David Schummers, vice president of marketing, was asked about Auris's refusal to disclose because "Auris is now in a state of high confidentiality."

Founded in 2007 in Auris: This makes people wonder: What is Auris doing?

The official website also lists current board members, in addition to Frederic H. Moll, Ajay Royan who founded Mithril Capital, Peter Hébert, co-founder of Lux Capital, and Bijan Salehizadeh, co-founder of NaviMed Capital, are the strengths of the industry. .

On April 20 this year, Auris acquired Hansen Medical, a formerly founded by Dr. Moll, for $4 per share, which is a total of about $80 million. As a result of this transaction, some of Hansen's previous major shareholders also promised to inject approximately 49 million into Auris Surgical Robotics. The deal will give Auris control of three different types of surgical robots. “Hansen’s achievements in endovascular surgery robots are already at the forefront of technology,” Moll commented. “The business opportunities for high-flexibility robots are very large. I am looking forward to helping us grow this block with this Hansen merger. Market."

Auris has been silent for nearly a decade, but from the signs of these financing and acquisitions, they are clearly laying the groundwork for the later story.

Dawning: the new product "ARES Robot"

Schematic of the ARES surgical robot - patent application from Auris

This year, at the end of May, Auris' first medical robot, the ARES surgical robot, was approved by the US Food and Drug Administration (FDA) and is now available for clinical diagnosis and treatment. The full name of ARES is the Auris Robotic Endoscopy System (Auris Robotic Remote System). There are rumors that the ARES robot developed by Auris Surgical will be used for cataract surgery, and therefore applied for some patents in related fields. But according to an observer in the IEEE Spectrum magazine, Auris's ambition is far more than that simple. According to some employees of the company, Auris is "inventing a new generation of surgical robots that allow robots to be used in medical procedures for various types of diseases."

According to the patent documents submitted by the company, Auris is now focusing on a so-called "intraluminal" surgical method, that is, to make the surgical robot through the natural opening of the human body (especially the oral cavity) to solve the throat, lungs, Digestive system problems. In traditional endoscopic surgery, in order to introduce the endoscopic tool into the patient's body by lever or with a turntable tool, the doctor often uses a "twisted" posture to complete the operation and is exposed to X-rays for a long time. The ARES robot not only avoids these situations by remote operation, but also increases the accuracy.

Because "intraluminal" surgical procedures do not cause open wounds and do not require extensive anesthesia, ARES robots can reduce the risk of surgery in patients with more severe physical conditions. The American Society of Gastrointestinal Endoscopic Surgeons estimates that in the United States, endoluminal surgery can help more than 1 million overweight or acid reflux patients successfully treat the disease each year. According to the "IEEE Spectrum" magazine, this robotic system has at least a successful clinical operation. The FDA has demonstrated that ARES robots can be used in bronchoscopy for the treatment of lung diseases.

In a patent document by Auris Surgical, surgical tools such as lasers, medical forceps, medical needles, grippers, scalpels, and the like, and the possibility of performing a series of operations such as biopsy, stomach repair, and tumor resection are mentioned.

Ariel Waldman, co-founder of Science Hack Day, is building Auris' hardware and software interface, which he described as "a groundbreaking robotic surgery system." In one experiment, Auris' robotic surgery system successfully performed a respiratory endoscopic procedure, diagnosed 9 cancer patients from 15 suspected patients, and extracted biopsies. No side effects occurred during the whole operation, which also marked them. The technology has great prospects in clinical diagnosis and surgical treatment.

Frederic Moll's decades of experience in the field of surgical robots may bring more technological innovations to the world.

The main development trend of medical robots in the future:

(1) The use of all-factor collaborative innovation in medical research and research has become inevitable.

(2) Specialized medical robots will become a product development trend.

(3) Financial capital plays an increasingly important role in the medical robot industry.

(4) Further development of the precise medical concept.

Attachment: Finally, there are six companies with technical strength in the field of medical robots at home and abroad, including three exoskeleton rehabilitation robot companies and three surgical robot companies.

1. Ekso Bionics

Ekso Bionics is a publicly traded company that specializes in medical and assistant robotics. Ekso Bionics, formerly Berkeley Bionics, was founded in 2005 in Berkeley, California. This company is a pioneer in the application of machine exoskeletons to improve human athletic ability. Since its inception, Ekso Bionics has partnered with world-class research institutes such as the University of Berkeley, receiving research funding from the Department of Defense and patenting technology from Lockheed Martin.

Ekso Bionics is an exoskeleton robot that uses the principle of bionics to allow individuals with lower limbs to stand up and walk on the ground with weight support and four-point compensation. The achievement of walking is to initiate walking by the user's forward weight movement, and the battery-powered motor drives the legs and replaces the functions of the neuromuscular.

2, Cyberdyne

A non-listed company that specializes in exoskeleton rehabilitation robots. The company is located in Ibaraki, Japan. Cyberdyne commercialized Professor Shan Haijia and his invention at the University of Tsukuba laboratory. The company's products are hybrid auxiliary limbs and have been developed to assist the lower limbs and robotic arms.

The most attractive aspect of Cyberdyne is mind control. The human nervous system and muscles emit a weak electrical signal when the brain intends to move the limb, and a series of sensors mounted on the exoskeleton continuously monitor these signals and act accordingly.

3, Open Bionics

Open Bionics is a privately held company specializing in medical, assistant and operational robots. The company's products are affordable machine prosthetic arms.

The Open Bionics robot has the same weight as the human hand and is connected to the arm muscles via medical electrodes. When the arm muscles contract, there is an electrical signal on the surface of the skin. The sensor takes this signal and passes it to the robot.

4. Intuitive Surgical

Intuitive Surgical is headquartered in California, USA, and the company's Da Vinci robot is the well-deserved boss of surgical robots. In the United States, Da Vinci surgical robots are very popular, as long as they are small-scale hospitals, they will definitely be equipped with Da Vinci robots.

The Da Vinci Surgical Robot is the first robot-assisted surgical system developed by Intuitive Surgical. Minimally invasive surgery, mainly for urology, such as prostatectomy, has been widely used in many disciplines, including gynaecological surgery, cardiac surgery, and pediatric surgery.

5. Titan Medical

Titan Medical is a publicly traded company specializing in surgical robots. The company is headquartered in Toronto, Ontario, Canada. TitanMedical specializes in the design, development and commercialization of new robotic surgical techniques, and the company's SPORT surgical system is being developed for minimally invasive surgery.

Titan Medical's primary intellectual property is the design patent for its single-hole equipment. The robot platform is flexible and agile, with a small footprint and lower cost. The company focuses on three types of surgery: general surgery (cholecystectomy, appendectomy), gynecology (benign tumor of hysterectomy), and urology.

6, Tianzhi Hang

Beijing Tianzhihang Medical Technology Co., Ltd. is an emerging intelligent medical robot technology company. The company focuses on computer-assisted surgical navigation and medical robots, providing clinical data sharing and telemedicine services to medical institutions at all levels. At present, Tianzhihang has completed the B round of financing, and is a company with a number of independent intellectual property rights.

Tianzhihang's main product is an orthopedic navigation robot, which is a kind of surgical robot. This technology can significantly improve the quality of orthopedic surgery and improve the working environment of doctors.

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